Multi-drug resistance (MDR1) gene and P-glycoprotein influence on pharmacokinetic and pharmacodymanic of therapeutic drugs

(MDR1) gene expressed in tumor cells and also in several normal tissues, such as intestine, liver, kidney, blood-brain barrier, spinal cord, and placenta.P-gp has been identified in mice, rat, bovine, Deviled Egg Holder monkey, rodents, and human beings and has been receiving a particular clinical relevance because this protein expression limits br

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Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes

Ketones, prevalent in many biologically significant molecules, require the development of novel methods to synthesize these structures, which is a critical endeavor in organic synthesis.Transition metal catalysis has proven to be an effective method for synthesizing ketones.However, Bed Pans the scope of these substrates remains relatively limited,

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